![]() ![]() Therapy resistance not only includes the traditionally well-established innate and acquired tumour drug resistance, but it also includes resistance to treatment such as chemo or radiotherapy, immune- and targeted-therapies (Burrell and Swanton 2016 Assaraf et al. Frequently, patients with resistance also develop more metastases, and given that metastasis is the major cause of cancer-related deaths in human carcinomas, it is important to overcome therapy resistance by using new targeted-therapy strategies. ![]() At present, one of the most important challenges in oncology is to overcome therapy resistance, as it is a persistent problem for cancer patient management.
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